As a source of human suffering, a barrier to workplace productivity, a burden on families and a driver of medical costs, mental illness amounts to an unparalleled public health crisis. Fortunately, there’s an abundance of smart thinking on how to improve the lives of people who struggle with major depression, schizophrenia, bipolar disorder, and other serious conditions. In this report, Syneos Health has synthesized some of this analysis, with particular attention to the recommendations, strategies and aspirations of patient advocacy groups. We have also collected insights from pharmaceutical companies, payers and other key stakeholders. Amidst great uncertainty in the healthcare environments of the U.S. and Europe, Syneos Health hopes to shine a light on unique challenges in mental health disorders and some possible solutions.